CRISPR-activated Oct4 as #GeneTherapy for #Progeria (LmnaC698G) & natural aged🐭
#HutchinsonGilfordProgeriaSyndrome

Polyethylenimine-cationic gold nanoparticle iv.

Do we need an aortotropic vector for #AorticAneurysm?

Dr. Jongpil Kim lab @AgingCell 2023
https://onlinelibrary.wiley.com/doi/10.1111/acel.13825

Through Oct4 expression is only transiently activated for 2 weeks in 50% aortic SMCs (by day 5 delivery) in progeria mice, but with an amazing long-lasting benefits on SMC vitality, arterial stiffness, progerin, multi-organ ( kidney, spleen, muscle, lung, and skin) senescence transcriptional profile, lifespan w/o apparent dysplasia