Effects of #Aneuploidy on cell behavior & function

Cause:
ROS
DNA replication
mitosis
mechanical confinement

Direct dosage + secondary Effect:
Redox, bioenergetic, proteostasis, Osmosis
Cancer, Aging

Dr Rong Li & Jin Zhu Nature Reviews MCB 2023
https://www.nature.com/articles/s41580-021-00436-9

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Any evidence on #Aneuploidy in cardiovascular biology?

From Abraham Aviv lab @ATHjournal 2001

Age-dependent aneuploidy & telomere length of the human vascular endothelium
https://www.atherosclerosis-journal.com/article/S0021-9150(01)00506-8/fulltext

Tetrasomy Chr6 Chr16
Loss ChrY

Aneuploidy in cardiovascular diseases?🧐

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Mice with #SpindleAssemblyCheckpoint protein BubR1 deficiency have a spectrum of vascular defects

Vascular BubR1 1/3

Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1

Dr. Jan van Deursen lab @StrokeAHA_ASA 2007
https://www.ahajournals.org/doi/10.1161/01.STR.0000257967.86132.01

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Vascular BubR1 2/3

BubR1 Insufficiency Inhibits #NeointimalHyperplasia Through Impaired Vascular #SmoothMuscleCell Proliferation in Mice

Dr. Takuya Matsumoto lab @atvbahajournals 2014
https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304737
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Vascular BubR1 3/3

BubR1 insufficiency impairs #Angiogenesis in aging and in experimental critical limb ischemic mice

Dr. Takuya Matsumoto lab @JVascSurg 2018
https://www.jvascsurg.org/article/S0741-5214(17)32041-4/fulltext