I am thrilled to announce the publication of our most recent paper, which can be found at https://doi.org/10.1021/acs.analchem.2c04365. We couple hydroxyl radical protein footprinting inline with weak anion exchange chromatography to measure the structural changes caused by phosphorylation/dephosphorylation of specific residues in a protein DURING a phosphatase reaction! This work opens up structural analysis of a wide variety of dynamic systems, where a particular conformer or proteoform cannot be isolated for high res structure elucidation. Very proud of this work, and of the group members that made it possible. #TeamMassSpec @strucbio