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@xtaldave Depends on what you mean by "specific". These interactions often have some flexibility, but it's not just an ion exchange resin; the pattern of sulfates usually matters. It's rarely a case of "the more sulfo groups, the better".

@JoshuaSharp @xtaldave probably in this case it may be, I agree with Dave, I would be quite stunned to see seuquence/sulfate pattern specificity in binding to histone H3...

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