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I think I have spent the first three weeks of 2023 preparing reports. My brain feels like sludge. Hopefully I will be done with at least two of them this week. Ugh.

@AmyPetty Oh no! I mean, I'm glad it's not worse, but that's awful!

Hamline U update: faculty votes overwhelmingly no confidence in president who presided over free speech debacle. FAAFO.

hamlineoracle.com/10822/news/h

@xtaldave Depends on what you mean by "specific". These interactions often have some flexibility, but it's not just an ion exchange resin; the pattern of sulfates usually matters. It's rarely a case of "the more sulfo groups, the better".

Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis
pnas.org/doi/abs/10.1073/pnas.

Looks Interesting. Will have to dig into this and find out why an 18-mer...

#Glycotime #Proteoglycans #Science #Research

I just wrote a short piece over on post.news about how the h-index rose to prominence because it was a clever UI hack—and now that the UI hack is no longer needed, it may seem like a curious choice of bibliometric measure.

Here's the link if you want to read it there.

post.news/article/2KNv9uat3nL8

I'll serialize here as well, below.

cen.acs.org/pharmaceuticals/ne

Why are they charging so much for the drug? According to the developers:

“When it comes to the very high unmet need and the gravity of the disease, there has been recommendations for the use of a higher willingness-to-pay threshold. And definitely this is the case for Alzheimer’s disease.”

Because they can.

Superb structural glycobiology from Joel Bloch with Ethan Goddard-Borger & Kaspar Locher who solved the structure of tryptophan C-mannosyltransferase ! congratulations

nature.com/articles/s41589-022

#glycotime

Everything about this story is just appalling: University administrators, and apparently even student journalists, have apparently decided that material a particular religious group considers “blasphemous” is therefore “harmful.” They cannot have thought through the consequences of applying that idiotic principle consistently. insidehighered.com/news/2023/0

Amid a raft of hospital closures, Mississippi Gov. Tate Reeves cautioned lawmakers against rushing to provide funding for ailing hospitals during a press conference on Jan. 3, 2023, saying that “keeping inefficient systems is not a good answer.”

mississippifreepress.org/30116

@kkmurray It's the latter. Twitter is very hardline when it comes to nomenclaturomics.

@AmyPetty At the end the aliens are still in power, still control their human collaborators, and just have to fix the transmitter. The heroes of the resistance are all dead.

I know that facts don't matter so much during a moral panic, but I'll just say that I teach a class every year at Stanford that tackles hate speech, violence, terrorism, child exploitation, suicide and other really difficult topics and use a lot of these words with no difficulties.

I do give my students a talk up front about the content of the course and the need to be resilient if you want to make a positive impact in this field, but so far no complaints.

reason.com/2022/12/21/stanford

Some advices for a better #Mastodon experience:

1. Avoid massive automated cross-posting from #Twitter

2. When writing threads, set public visibility 🌍 to the first message and unlisted 🔓 to the other ones

3. Boost messages that you like. We're all looking for interesting people to follow, and boosting helps a lot!

4. Use hashtags! It's the only way to find your messages via Search 🔍

5. If your message is about a sensitive topic, add content warning to it

6. Add text description to images

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