Combinatorial interpretation of BMP and WNT allows BMP to act as a morphogen in time but not in concentration.
"[...] varying the duration of #BMP #signaling leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces #hPSCs to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous #Wnt signaling."
https://www.biorxiv.org/content/10.1101/2022.11.11.516212v1?rss=1
#DevBio #CellFate #GermLayers #morphogens #Differentiation
