Important new paper on #DNAreplication from Pierre Murat in Julian Sale's group at the LMB in Cambridge. Interestingly there is a clear signature of mutation surrounding replication origins in mammalian cells such that they mutate more rapidly than non-origin sequences. A consequence of this is presumably that origin of replication move around rapidly over evolutionary timescales (and potentially even in cancer evolution). Interesting from an evolutionary perspective as some eukaryotes (e.g. cerevisiae) have quite localised origins- maintaining these must require quite strong selection- why are localised origins important in some eukaryotes and not others? Link to paper is here:
https://www.science.org/doi/10.1126/sciadv.add3686