#DNAnanotech #preprint
4 DNA origami structures (helix-bundles and ring) used as scaffolds to initiate assembly of CCMV^ (virus) coat protein, takeaways -
- capsid shape, size control
- DNA encapsulation (nuclease resistant)
- tubular origami structure preferred, negative curvature not well tolerated

*imagining 🪆*
^CCMV's reversible assembly process is well characterized, pH/ionic strength control --> formation of hexagonal sheets, tubes

Building on prior work (from the same lab) 2014,
https://pubs.acs.org/doi/abs/10.1021/nl500677j

DNA origami directed virus capsid polymorphism @biorxivpreprint https://biorxiv.org/content/10.1101/2022.11.07.515152v1