Leo Betschart @betschart@social.cleverlibre.org

⚗️ Using the Bunsen burner for the final step of a complex total synthesis?

📰 #OpenAccess #TotalSynthesis of Euphorikanin A by Erick Carreira and colleagues from #ETH Zurich (#Switzerland) published in #JACS. A late-stage atrospecific cascade reaction led to the core structure of the terpene and pyrrolysis finally yielded the natural product.

#chemistry #research #science

https://pubs.acs.org/doi/10.1021/jacs.3c11000

Terrific essay on Nazis and mouse poop (no really): https://davekarpf.substack.com/p/on-substack-nazis-laissez-faire-tech

Took me way too long in my career to add such a paragraph to a paper. Y'all should cite the software you use!

https://www.sciencedirect.com/science/article/pii/S0378873323000825

#rstats #OpenScience

The strain on scientific publishing 📄:

The publishing sector has a problem. Scientists are overwhelmed, editors are overworked, special issue invitations are constant, research paper mills, article retractions, journal delistings… JUST WHAT IS GOING ON!?

Myself, @pablo, @Paolo, and @Dan have spent the last few months investigating just that.
https://arxiv.org/abs/2309.15884

A thread🧵1/n

#AcademicChatter #PublishOrPerish #Elsevier #Springer #MDPI #Wiley #Frontiers #PhDAdvice #PhDChat #SciComm

Dismayed to notice that in 2003 I published an article containing a sentence with an unmatched left parenthesis so that everything I’ve published in the last twenty years has been part of one extremely long parenthetical remark.

It was one year ago today that David Smith emailed me out of the blue, asking about my work on computing Heesch numbers. A few days later he tipped his hand and showed me a drawing of the hat polykite for the first time. Happy Aperiodic Monotile day to all who celebrate.

Good morning to everyone who hasn't exploded toxic materials over the Gulf of Mexico and on the social media site they bought for $44b.

If you're new here, and considering whether this space could become a social home for you:

Many of us have been here for a few years, since well before Threads, BlueSky, Spoutible, Post, Hive, Pebble, Cohost, Blurble, Blarble and Blorble.

We've made it through waves of user migrations, claims of imminent demise, and tech bros telling us we're doing it all wrong.

Years later, we're still here. Ad-free. Non-profit. Open source. Millions strong.

Stay a while. You might just like it. :)

I have seen all 4 of these lines of best fit in published peer-reviewed papers and oddly the top left is probably the rarest type 📉

If people keep telling you to meditate or “practice mindfulness” and listening to an improbably youthful Gwyneth Paltrow wannabe chat shit for twenty minutes on an overpriced app that makes dubious claims of efficacy doesn’t do it for you, a brisk walk in the park listening to drum’n’bass, hardcore breakbeat, jungle and so on may give you the same purported benefits without the aesthetic awfulness.

For those who aren’t into bleepy bloop music, I’m told fast/aggressive metal works well too.

I don't (ever) post Tumblr screenshots I found on other websites, but this is, the correct shit

post mortem on the Gino case, by a #whistleblower
https://www.theorgplumber.com/posts/statement/
#fraud #psychology