bonifartius 𒂼𒄄 @bonifartius@social.cleverlibre.org

Now that I have the opportunity, let me #introduce our quality-diversity #compchem algorithm to Mastadon. It's based on @janhjensen 's generative algorithm. We avoid stagnation issues, and illuminates opportunities across chemical space, and outperforms #deeplearning approaches!

Code: https://github.com/Jonas-Verhellen/Argenomic

Paper: https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc03544k

#drugdesign #optimisation #algorithm #chemistry #generative

#GNOME replaces its mailing lists with Discourse:
https://mail.gnome.org/archives/desktop-devel-list/2022-September/msg00018.html

As someone who grew at a time where email was an unquestioned, decentralized foundation of #FreeSoftware workflows, moves like leave a bad taste in my mouth. I understand how Discourse facilitates onboarding, but the idea of delegating to a central server and using the browser as the sole user interface remains unappealing to me.

Getting old?

@toast @Halo @Loded-Diaper @Minty @revmagdalen @sim

I think Tolkien was on to something when he said Anarchism or Unconstitutional Monarchy. If I had to only deal with a King that took 3% of my yearly income (and that's it) and was chiefly interested in horses or collecting stamps and only real power was to be able to sack his Vizier (or whatever they're called) simply for not liking him, FUCK YES I'd take that over this shit system we have now in the US.

I CW things voluntarily because I don't like to upset people. But I would NEVER demand anyone CW anything they want to say. Nobody should.

Choose who you follow based on whether you're comfortable with their posts or not. Don't be demanding others censor themselves for you.

Lian Li PC-777 (2005)

there is no cloud, only thinkpads without screens in other people's homes

No time to explain just get in

Oh look: a fake CA tied to a surveillance company. Nothing to see here. https://www.washingtonpost.com/technology/2022/11/08/trustcor-internet-addresses-government-connections/

Oh shit what have I done

It's unfunny

mutuals repost this

@revmagdalen Twitter was already destroyed by an oligarch. It's extremely corporate. Hasn't it always had one? You are not on twitter now. Why do you want to make a different social media platform just like twitter? Many of us were cast out from twitter over the years too... and twitter has been a miserable experience for us. Why would you bring it with you to us when we wanted to escape it? You are defending twitter culture which is toxic and exploits people for advertisers, branding and corporations. A lot of its practices encourage ragebaiting, the algo feeds this. I don't need random people coming into my threads to tell me that they have blocked me which is what started my rant. I don't need to know. This is just toxic behaviour passed to us. If someone must block me, they can block and move on.

> You know how this place was mostly screaming into dead air before we got here?

lol. lmao.

some of the best and most important personal relationships of my life were forged here, without the "help" of an algorithmic timeline.