MYC vs Therapy (review)

"Altogether, the fitness of MYC-overexpressing cells depends on a fragile equilibrium between ambivalent signals that not only elicit therapy resistance, but also provide new therapeutic opportunities. Here, we review the known links between MYC and either resistance or sensitization to therapeutic intervention, and draw future perspective to exploit these pharmaco-genetic interactions toward improved cancer patient outcomes."

https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13319