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A role for the STING pathway in nervous system regeneration.
"Here, we found that protein tyrosine phosphatase non-receptor type 2 (Ptpn2) inhibition combined with low-dose IFNγ enhances CNS axon regeneration by amplifying IFNγ-STAT1 signaling, with the cGAS-STING pathway as the functional downstream signaling. In the PNS, the IFNγ-cGAS-STING axis is coordinated by both neuronal and non-neuronal cells to support spontaneous axon regeneration."
https://www.cell.com/neuron/fulltext/S0896-6273(22)00961-8#.Y25_9yuiGgQ.twitter
