"Antibody-drug conjugates (ADCs) have a long but somewhat convoluted history in drug discovery. The idea seems straightforward, though: combining the extraordinary selectivity and long half-lives of antibody proteins with the target-directed effects of a small-molecule drug. In practice, as is so often the case, it’s Not So Simple."

#Immunology #DrugDevelopment #antibody

https://www.science.org/content/blog-post/mysteries-antibody-drug-conjugates