"MFN2 Q400 is the first known natural mitophagy- and shape change-defective MFN2 mutant. Its unique profile of dysfunction evokes mitophagic cardiomyopathy, suggesting a mechanism for its enrichment in clinical #cardiomyopathy."

#preprint #mitochondria

https://www.biorxiv.org/content/10.1101/2022.11.22.517462v1?med=mas