Thiago @cyrilpedia latest research update is out: A new class of antibiotics delivers promising trial results against tuberculosis nature.com/articles/d41591-022

@gpollara @mucida Phase II data at the moment, but an interesting approach. The same company (which has since been phagocytosed by Pfizer) already developed an anti fungal based on a difference anti tRNA synthetase. So fingers crossed. The science is pretty cool, a set of boron-based compounds they've been working on for a while.

@cyrilpedia @mucida ah v interesting, didn't know the background to this drug, thank you

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@gpollara @mucida If you want to have a look, here's their earlier work on the anti fungal agent - but the basic mechanism is the same clogging the editing domain of the synthetase, which then blocks the catalytic function. Very cool

science.org/doi/10.1126/scienc

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