"Here, we developed a computational model to interrogate antibody evolution by affinity maturation after immunization with two types of immunogens: a chimeric heterotrimeric antigen that is enriched for the RBS epitope relative to other B cell epitopes, and a cocktail composed of three non-epitope-enriched homotrimeric antigens that comprise the chimera."

#Immunology #Preprint

https://www.biorxiv.org/content/10.1101/2022.12.02.518838v1?med=mas