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Really cool work in #Immunity by Annika Frede, Eduardo Villablanca et al. using a mouse DSS model of intestinal damage
"Although neutrophils and monocytes expanded transiently during the inflammatory process, B cells continued to expand during the recovery phase, becoming the most dominant cell type within the colon LP. Using flow cytometry, single-cell RNA sequencing (scRNA-seq), immunofluorescence, and RNAscope, we identified an interferon (IFN)-induced B cell subtype that accumulates in damaged areas of the regenerating colon. B cell depletion (BCD) during the recovery phase enhanced tissue repair and a transcriptomic program associated with the extracellular matrix (ECM) remodeling. "
