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My latest clinical pipeline column for Nature Medicine is a look at a drug recently approved by the #FDA to delay the onset of type 1 diabetes.
It's a direct descendant of the very first monoclonal ever approved for clinical use.
#Diabetes #Type1Diabetes #DrugDevelopment #DrugDiscovery #NatureMedicine #Immunology #MonoclonalAntibody
Here's the fulcrum of this story, the paper where the Bluestone group and collaborators turn the mouse anti-human CD3 monoclonal into a chimeric, non-Fc activating molecule: Alegre et al, 1994
#MonoclonalAntibody #MolecularBiology #AntibodyEnginering #DrugDiscovery #DrugDevelopment #NatureMedicine #Diabetes #Type1Diabetes #Immunotherapy
https://pubmed.ncbi.nlm.nih.gov/8009586/