"In the absence of MgrB, PhoQ appears to be insensitive to antimicrobial peptides, including the commonly used C18G. MgrB mediates the sensing of C18G by dissociating from and thus derepressing PhoQ. Our findings reveal the inhibitory mechanism of the small protein MgrB and uncover its importance in antimicrobial peptide sensing."

#AntimicrobialPeptide #Preprint

https://www.biorxiv.org/content/10.1101/2022.12.22.521624v1