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"Patterns extracted from proteins in the Protein Data Bank (PDB) provide a ready “parts list,” circumventing the folding process entirely. These patterns are “fully baked.” That is, a pattern extracted from a solved structure in the PDB is fully preorganized; any physical–chemical organizing interactions have already been realized during folding. The situation is analogous to interpreting a movie by fast-forwarding to the final scene without first watching the previous two hours; we know how it ends, but we don’t know why."
@cyrilpedia
It’s been awhile since I’ve read an opinion piece I’ve agreed with so much. Structure prediction is a powerful tool, but it is only an early step in our understanding. Thanks for sharing!