"Adulthood-only downregulation of insulin/IGF-1 signaling (IIS), an evolutionarily conserved pathway regulating resource allocation between somatic maintenance and reproduction, increases life span without fecundity cost in the nematode, Caenorhabditis elegans. However, long-term multigenerational effects of reduced IIS remain unexplored and are proposed to carry costs for offspring quality."
cc @Odedrechavi
#Celegans #Epigenetics #Insulin

https://onlinelibrary.wiley.com/doi/10.1111/evo.14640?af=R