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"Here, we describe the development and validation of a computational program, which designs strain-specific CRISPR guide RNAs that can be utilized to modify complex consortia. As a proof of concept, we applied the program to two applications: the isolation of specific microbes from consortia and the removal of specific microbes from consortia. This technique has many practical applications, including addressing the problem of antibiotic-resistant microbes and isolating useful microbes from the environment."
#CRISPR #Microbiology
