'Gene duplication and diversification allow hosts to mutate otherwise essential genes, whereas changes in transcriptional regulation can selectively activate genes should their constitutive expression be detrimental. To counter mutational tolerance, it has been suggested that viruses target essential genes as host cofactors, because the genes are less prone to variability'

#Virology #HostPathogen #RNASplicing

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001934