"he mutational signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers. However, data linking individual APOBEC3 proteins to cancer mutagenesis in vivo are limited. Here, we showed that transgenic expression of human APOBEC3G promotes mutagenesis, genomic instability, and kataegis, leading to shorter survival in a murine bladder cancer model."

https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-22-2912/711511/The-cytidine-deaminase-APOBEC3G-contributes-to?redirectedFrom=fulltext