Analysis of copy number variation following platinum-based chemo.

"Here, we demonstrate that platinum-based chemotherapies also leave a type of larger mutational footprints in the genomes of exposed cells. These consist in an increase of chromosomal fragments of copy number between 1 and 4 and length below 40 Mb, possibly resulting from an increased frequency of double strand breaks in the chromosomes of the cells of exposed patients."

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010634