'Here, we show that in a mouse model of MS, T cell-specific Ahrknockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids.'

#Immunology #MucosalImmunology

Merchak et al @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002000