'Multistep IgE mast cell desensitization is a dose- and time-regulated process that blocks β-hexosaminidase, impacting membrane and cytoskeletal movements. Signal transduction is uncoupled, favoring early phosphorylation of SHIP-1. Silencing SHIP-1 impairs desensitization without implicating its phosphatase function'

#Immunology #allergy #MastCell

https://journals.aai.org/jimmunol/article/210/6/709/238977/Multistep-IgE-Mast-Cell-Desensitization-Is-a-Dose