Interesting #preprint from the Papavasiliou group at DKFZ/Heidelberg.

"Here, we have employed site-directed RNA editing to specifically alter MHC-presented tumor epitopes at the transcript level, with no modification to the genomic DNA, to modulate their antigenicity and recognition by cognate T-cell receptors (TCR). We demonstrate that RNA editing can be employed as a precision tool to specifically modulate antigenicity through the formation of RNA editing derived neoepitopes, which we have termed "editopes"'.

#Immunology #immunotherapy

https://www.biorxiv.org/content/10.1101/2023.03.16.532918v1?med=mas