"Whether perturbations of any of these endosome-related processes can give rise to TLR7 gain-of-function and facilitate self-reactivity has not been investigated. Here, we show that a dysregulated endosomal compartment leads to unrestricted TLR7 signaling and human lupus."

#Preprint #Immunology #InnateImmunity #Lupus #TollLikeReceptor

https://www.biorxiv.org/content/10.1101/2023.04.03.535356v1