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'We found that the follicular dendritic cell network was smaller in aged mice. Furthermore, the TFH cells that are normally localized within the light zone were instead dispersed throughout the GC in aged mice (Fig. 1), owing to enhanced expression of CXCR4 (a CXCL12 receptor) that directed the TFH cells to the CXCL12-rich dark zone.'
#Immunology #GerminalCenter
