'Even while I was saying that, though, it wasn't quite accurate - I mean, amphetamine (for one) definitely suppresses feeding behavior, just at a rather unacceptable cost in side effects. But for many years, that was the choice: a long list of things that didn't work, or a very short list of things that did but caused serious trouble along the way. The GLP-1 agonists are the first pharmacological class that seems to be breaking out of that dichotomy.'

https://www.science.org/content/blog-post/new-world-obesity-therapies