'What to do? You’ll see many suggestions in the Nature piece. A big one is tightening up criteria for considering a published trial in reviews and meta-analyses, since these things contaminate those papers in turn. There’s also having journals ask (much) more often for anonymized trial data as part of the manuscript review process, although that means a lot more work in the editorial process. And back at the source, there’s trying to get countries with data-trust problems to alter the policies that lead to this stuff in the first place.'

https://www.science.org/content/blog-post/too-many-bad-clinical-trials