"This study highlighted a primordial PD-L1/BTLA coinhibitory axis that regulates CD8+ T cell activation in teleost fish and may act as an alternative to the PD-L1/PD-1 axis in mammals. It also revealed a previously unrecognized strategy for E. tarda immune evasion by inducing CD8+ T cell tolerance to target Mϕ cells through eliciting the PD-L1/BTLA checkpoint pathway."
#Immunology #zebrafish

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300217/265791/PD-L1-BTLA-Checkpoint-Axis-Exploited-for-Bacterial