'Lifespan reduction was also observed when Atg1 or Atg18 was knocked down in adult fly enteroblasts and midgut stem cells. Over-expression of wild type Atg1 in adult fly muscle or adipocytes reduces lifespan and causes accumulation of high levels of ubiquitinated protein aggregates in muscles'

https://academic.oup.com/genetics/advance-article-abstract/doi/10.1093/genetics/iyad154/7245786?redirectedFrom=fulltext