'Although all complement pathways have been implicated in COVID-19 pathogenesis, the upstream drivers and downstream effects on tissue injury remain poorly defined. We demonstrate that complement activation is primarily mediated by the alternative pathway, and we provide a comprehensive atlas of the complement alterations around the time of respiratory deterioration.'

#Covid19 #covıd #sarscov2 #immunology #inflammation

https://www.science.org/doi/10.1126/scitranslmed.adi0252