"Nobel announcement disagreements often focus on whether the recipients deserved it, or not. But the 2023 Medicine and Physiology prize has received near universal applause: the science that it rewards has already saved the lives of many millions, and (maybe most importantly) has transformed how we think about emerging infectious diseases and other diseases. But the real intrigue surrounds its backstory. Karikó was forced to retire from her position at the University of Pennsylvania in 2013. The much-discussed reasons are familiar villains: the inability to secure major grant funding from the large agencies, and other markers of success in the biomedicine machine."