The effects of the CTLA4 deletion were not very surprising, what's fascinating here is how it compares to the double mutants (PD1/CTLA4).

"CTLA4 disrupted CART19 cells display prolonged surface CAR expression, increased proliferation, and enhanced CART19 effector function supported by unopposed CD28 co-stimulation, which is lost in CART19 cells deficient for both PD-1 and CTLA4"

#Immunology #Immunotherapy #CheckpointInhibitor #CTLA4 #CARTcells

https://www.cell.com/immunity/fulltext/S1074-7613(23)00407-7#secsectitle0075