"Here, we demonstrate that insulin receptors (Insr) in KrasG12D-expressing pancreatic acinar cells are dispensable for glucose homeostasis but necessary for hyperinsulinemia-driven PanIN formation in the context of diet-induced hyperinsulinemia and obesity."

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00372-8?rss=yes&utm_source=dlvr.it&utm_medium=twitter