"Goitre was embarrassing, ugly and a subject for humour, so Eggenberger began his presentation with the image of the Madonna from Albrecht Dürer’s Dresden Altarpiece: unimpeachable, unmockable and exhibiting, he claimed, an obvious goitre."
https://www.lrb.co.uk/the-paper/v45/n23/jonah-goodman/a-national-evil