"Through tissue-specific manipulation of Nptx2, the authors demonstrated that the pituitary was a major source of NPTX2 in the serum, and the increased NPTX2 secretion by the pituitary affected immune balance by regulating the blood neutrophil-to-lymphocyte ratio. Intriguingly, Nptx2 up-regulation in corticotropes seemed to depend on IL-6 but not other cytokines tested."
#Immunology #Neuroimmunology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002440