"Suppressive activity is enriched among CD4+ Tconv cells marked by expression of C-C motif receptor 8 (CCR8), which are found in mouse and human tumors. Upon Treg cell depletion, CCR8+ Tconv cells undergo systemic and intratumoral activation and expansion, and mediate IL-10–dependent suppression of antitumor immunity."
@cyrilpedia multiple layers of immune suppression in the tumor microenvironment
@ntoohm All of the above, in different mixes for different sites/different times of even the same tumor. And dont forget the wild card: antigen receptor repertoire bingo.
@cyrilpedia I wander what are the driving forces from the tumor that reprogram TILs. Metabolites? Small molecules? Low oxygen? Low glucose?