Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
It's like the Royal Navy weaponised carne de porco à alentejana.
(from Stanley Tucci's wonderful memoir, Taste).
Thiago Carvalho
boosted
Population health was already declining pre-covid - the pandemic has made it worse, partly through tens of millions of people getting sick with Covid, millions not fully recovering + general impact of an NHS in crisis for over a year.
Cost of living also adding pressure.
RT @guardian@twitter.com
UK economy being held back by worsening health of British public, Andy Haldane warns https://www.theguardian.com/business/2022/nov/09/uk-economy-being-held-back-by-worsening-health-of-british-public-andy-haldane-warns?utm_term=Autofeed&CMP=twt_gu&utm_medium&utm_source=Twitter#Echobox=1668020921
Thiago Carvalho
boosted
I have been asked what solutions exist for preprinting in #French rather than in English. I know HAL (https://doc.archives-ouvertes.fr/) but it isn't clear whether researchers based outside 🇫🇷 (e.g. from 🇨🇭) can use it. Does anyone know what solutions exist for non-English #preprinting? #preprint
Thiago Carvalho
boosted
A really great, clear and simple guide to Mastodon can be found here: https://mastodon.help
Please be patient with any glitches and bear in mind that Mastodon is run by volunteers who are dealing with a mahoosive influx of new people. ❤️
#MastodonHelp
#MastodonServers #Instances #ChoosingAnInstance #MastodonOnSmartphones #MastodonOnLaptops #MastononAccounts #MastodonTimelne #MastodonSearch #MastodonTrendingTopics #MastodonPrivacy #MastodonThreads #MastodonContentWarning #MastodonModeration
Plus we have cool tattoos
@marcdionne @meyer@mstdn.science
I'm always ready to write in support of your unique genius, Marc.
Thiago Carvalho
boosted
RT @PLOSBiology
Producing gene transfer agents can have benefits. Andrew Lang explores a new #PLOSBiology study showing that DNA transfer by these phage-like elements allows host cells with damaged DNA to repair DNA and survive. Primer: https://plos.io/3EiWpHV Paper: https://plos.io/3E0EyVR
"By comparing the highest-elevation frog, Nanorana parkeri, with its low-elevation relatives, we showed higher UV tolerance in N. parkeri after a time course UV exposure. Combined a chromosome-level reference genome of N. parkeri with large-scale transcriptomic and microRNA (miRNA) profiling, we showed a temporal expression pattern of UV defense genes in N. parkeri. Some miRNAs correlate with both cell cycle and immune genes in expression, suggesting their regulatory role involved in UV defense."
#Evolution
"Kitefin sharks (Dalatias licha) have been known about since the 18th century, but it was only in January 2020 that scientists saw them glowing in the dark for the first time. They are not the only bioluminescent sharks – roughly one in 10 species has that ability – but at up to 1.8 metres, kitefins are by far the biggest that have been found."
"If Aristotle had plugged his nose when he tasted the apple, he might have noticed that the apple sensation disappeared leaving only sweetness and perhaps some sourness—depending on the apple. He might have decided that the apple sensation was entirely different from the sweet and sour tastes, and he might have decided that there are six elementary sensations."
Thiago Carvalho
boosted
How the RNA vaccines activate the innate immune response & prime the adaptive response was one of the most frequent questions I got in 2020/2021.
"We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform"
#RNA #rnavaccines #Immunology #InnateImmunity
https://www.cell.com/immunity/fulltext/S1074-7613(22)00555-6
How the RNA vaccines activate the innate immune response & prime the adaptive response was one of the most frequent questions I got in 2020/2021.
"We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform"
#RNA #rnavaccines #Immunology #InnateImmunity
https://www.cell.com/immunity/fulltext/S1074-7613(22)00555-6
That's quite an opening:
"Defective host defenses later in life are associated with changes in immune system activity. The means to correct immune defects to ensure immunity in the elderly are undefined. In this study, we found that CD8+ T cells, which are necessary for anti-tumor immunity in young mice, are not required to eradicate the same cancers later in life."
(from the Kagan lab)
Thiago Carvalho
boosted
RT @lysergicdesigns@twitter.com
Our article reporting hyperfolder YFP (#hfYFP) and other fixative-resistant fluorescent proteins based on #mGreenLantern is now available at @naturemethods@twitter.com. hfYFP enhances electron- and expansion-microscopies, protein purification, and so much more! 🧵https://www.nature.com/articles/s41592-022-01660-7
🐦🔗: https://twitter.com/lysergicdesigns/status/1589734660531449856
Thiago Carvalho
boosted
RT @SandraM_Duran@twitter.com
Fully funded PhD position @ the new Traits & Ecosystems Lab @FRStewardship@twitter.com working with me on linking biodiversity observations to remote sensing to predict ecosystem function. Full ad on the link below @ESA_org@twitter.com @theATBC@twitter.com @NEON_sci@twitter.com https://traitsandecosystems.com/
🐦🔗: https://twitter.com/SandraM_Duran/status/1590525064474112000
Thiago Carvalho
boosted
Early on in the #monkeypox outbreak, there were so few deaths it seemed hard to square with the death rates from historically endemic countries. It is still true deaths have been lower in countries with access to MPX drugs & vaccines. But they had inched up. The 110 countries that have had reported nearly 80,000 cases this year have logged 44 deaths.
"Using an RNA FISH-Flow HIV-1 reactivation assay, we demonstrate that SLFN12 expression is enriched in infected cells positive for HIV-1 transcripts but negative for HIV-1 proteins. Thus, codon-usage dependent translation inhibition of HIV-1 proteins participates in HIV-1 latency and can restrict the amount of virus release after latency reversal."
#HIV #Latency #Preprint
Thiago Carvalho
boosted
Just a reminder about Mastodon.
Try not to directly upload videos here.
You have to remember that these videos have to be stored on the server that you're hosted on.
This would also eat up on available bandwidth, storage and memory resources of said servers and slow them down. Which would force server hosts to upgrade at a substantial cost.
Suggested idea...
Upload to YouTube, Vimeo or other video streaming services and share the link to the video here instead.
Thiago Carvalho
boosted
Great back-to-back read in @ScienceAdvances@twitter.com on how dynein-driven bulk microtubule retrograde flow in immature neurites drives specification of the axon: from Mithila Burute @KapiteinLukas@twitter.com et al: https://www.science.org/doi/10.1126/sciadv.abo2343 and from @MaxSchelski@twitter.com & Frank Bradke: https://www.science.org/doi/10.1126/sciadv.abo2336
You bet
"It’s now been 16 years since the publication of The Road, which makes the arrival of not one but two new McCarthy novels — rumours of which have abounded at least since he sold his archive to the Texas State University-San Marcos in 2009 — a major literary event."
https://www.ft.com/content/f3edb5d8-968e-4d0d-8bcf-ca920e1ea5df
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
