Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Amid Eli Lilly-Twitter Fiasco, Groups Call for End to Insulin Price Gouging
"The fake Eli Lilly account was right. Insulin should be free."
Thiago Carvalho
boosted
Hello Mastodon! This is the official account for the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).
We are a non-profit org focused on #InfectiousDisease and Clinical Microbiology for professionals in those areas.
We organise research grants, educational events and our annual congress #ECCMID2023 (www.eccmid.org) along with much more.
You can learn all about us on our website (www.escmid.org) and we hope to see you around!
Thiago Carvalho
boosted
We're lucky enough to host regular lectures from leading scientists, such as Gordon Freeman at Harvard Medical School. In this recent talk, he shared fascinating overview of what’s new in #cancer #immunotherapy research and his findings regarding B7-1 and B7-2 proteins. Learn more about PD-L1 and PD-1 and take a closer look at advances in checkpoint inhibitor / blockage approaches: https://youtu.be/CDgi3WWW8So
Thiago Carvalho
boosted
#introduction: I am obsessed with the biology of #hallucinations and #delusions.
I am a #newPI at the Francis Crick Institute, London. In our lab, the #Psychosis Collective, we study the neural circuits and immune processes underlying unfounded perceptions and thoughts 🐭 👤 . I look forward to great #neuroscience #immunology #neuroimmunology #psychiatry here!
This is me moving to London without ever having been to London before.
Add your own meme
"In a study published last week in the journal Proceedings of the Royal Society B, researchers identified evolutionary clues about these flies, including genes that may have helped turn their bristle-clad genitalia into blades that help them eat."
https://www.nytimes.com/2022/11/14/science/fruit-fly-vaginal-teeth.html
Thiago Carvalho
boosted
Still a few spots available to attend @ASNAmNat #Asilomar 2023 #ecoevo #conference.
Who says Shameless was cancelled?
"The BBC has learned that BP chief executive Bernard Looney was registered as a poor country delegate for COP27."
Thiago Carvalho
boosted
#Senescence #ImmuneSurveillance
Next-gen #Senolytic
#ImmuneCheckpointBlockade activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭#Aging+#NASH
Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
https://www.nature.com/articles/s41586-022-05388-4
Thiago Carvalho
boosted
Thrilled to share our lab's first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.
https://www.cell.com/cell-genomics/fulltext/S2666-979X(22)00170-7
Thiago Carvalho
boosted
UW Immunology is hiring up to TWO Assistant professors and ONE Associate professor! Big and vibrant scientific community in Seattle, amazing quality of life, and great colleagues. Come join us! Intended start date September 2023. Diverse candidates encouraged to apply!
Assistant Professor: http://apply.interfolio.com/115480
Associate Professor: http://apply.interfolio.com/115764
Thiago Carvalho
boosted
Looking for a #job in #academia in #ecology & #Evolution ?
Follow this group:
▶️ @jobsecoevo ◀️
PS1: IF you were following the group @joboffersecoevo, I recommend you unfollow it - as we'll be using the new group - with a simpler name - instead
PS2 - to receive future job adverts, follow THE GROUP not me! 🙃
Thiago Carvalho
boosted
Children in iron lung (1937) before the advent of the polio vaccine. The iron lung is a mechanical respirator that enables a person to breathe when muscle control is lost.
In the first half of the 20th century, polio was the leading cause of death in children and young adults. In extreme cases, the virus can cause spinal and respiratory paralysis, making it impossible to breathe. The iron lung saved countless lives. #vaccines #histmed #medhist #histodons #history #MedMastodon #ScienceMastodon
Thiago Carvalho
boosted
Our prospective Paxlovid rebound study with controls preprint is posted
By symptoms: ~12% rebound (19% Pax vs 7% controls)
By positive testing: ~5% rebound (14% Pax vs 9% controls)
Much lower than many estimates
https://www.medrxiv.org/content/10.1101/2022.11.14.22282195v1 by @JayPandit@twitter.com @michaelmina_lab@twitter.com @ScrippsRTI@twitter.com
#Telomeres #Telomerase #tumorigenesis #Preprint from Charles Kinzig, Titia de Lange et al
"Here, we aimed to determine whether telomerase can add telomeric DNA to DSBs in human cells and how this process is regulated. The data indicate that telomerase can create a functional neotelomere at a Cas9-induced DSB that bears the TS sequence at one 3′ end. The frequency of neotelomere formation is increased upon overexpression of telomerase, suggesting that the low level of telomerase in most human cells minimizes these deleterious events. In addition, neotelomere formation is inhibited by ATR signaling at resected DSBs. We discuss these findings in the context of genome instability during tumorigenesis, where neotelomere formation by telomerase might end BFB cycles as originally proposed by McClintock."
Thiago Carvalho
boosted
The miracle of insect metamorphosis appears to be brought on, in part, by a revival of gene transcription from the egg/embryonic stage.
This strikes me as a significant advance in our understanding of insect biology.
"It was late in 1972 — a year in which the science of genetic engineering really began to sizzle — that two California researchers announced the unusually tidy transfer of genetic information from one bacterium to another with help from a specialized enzyme. It was a scientifically heralded result, but behind the hoopla was just one small catch. The information transferred enabled a common human disease bacterium, E. coli, to resist not just one antibiotic, but two.
“Alarm bells should have rung,” writes @matthewcobb, in his deeply researched and often deeply troubling history of gene science."
https://www.nytimes.com/2022/11/14/books/review/as-gods-matthew-cobb.html
Thiago Carvalho
boosted
Job: PhD in disease ecology USA
#job #PhD #diseaseecology
#birds
In Tucson, #USA
Deadline 1 Dec 2022
More info: https://twitter.com/SabrinaMcnew/status/1591175329619800064
Thiago Carvalho
boosted
What if we could map the #genome, #transcriptome, and #proteome at single-cell spatial resolution across entire organs?
In this very nice review article, Jeffrey Moffitt et al. provide a comprehensive overview of the emerging landscape of #spatialprofiling technologies.
Article in Nature Reviews #Genetics: https://www.nature.com/articles/s41576-022-00515-3
#histology #pathology #multiomics #artificialintelligence #machinelearning
Thiago Carvalho
boosted
RT @HHMIJanelia@twitter.com
🚨 One week left 🚨
Applications for Group Leader & Sr. Group Leader positions in 🦠 4D Cellular Physiology, 🧠 Mechanistic Cognitive Neuroscience and 🖥️ Computation & Theory close Nov. 22.
Apply today ▶️ https://www.janelia.org/our-research/our-labs/group-leaders
🐦🔗: https://twitter.com/HHMIJanelia/status/1592540182896869376
Thiago Carvalho
boosted
My migration to Mastodon is complete! I deleted my Twitter account. I am an Associate Professor at The University of Washington. My interests are innate immunity, host-virus interactions, RNA regulation and host genetics. I am looking forward to interacting with everyone! #RNA #hostpathogeninteractions #immunology
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
