Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Five white egrets. 1927.

By Ohara Koson, Tokyo.

From Te Papa, Wellington https://collections.tepapa.govt.nz/object/1529420

#art

@StephenCurry
Sod it, I'm meme-ing that.

4 yr PhD in Manchester, UK: The evolution of nerves: understanding the roots of neurodegeneration

TRAINING in evol. biol., biochem., expansion or electron microsc., cell culture, #Drosophila genetics, #scicomm

SUPERVISION: Prokop/Allan/Ronshaugen

DETAILS: https://thenode.biologists.com/jobs/prokop

Interesting to see that Editas has paused their #CRISPR clinical trial on Leber congenital amaurosis. More a strategic decision rather than safety concerns over CRISPR therapy.

#CRISPR
#genetherapy

https://www.genengnews.com/topics/genome-editing/crispr-cas9-genome-editing/editas-medicine-pauses-trial-of-crispr-cas9-treatment-for-blindness-disorder/

Here's a terrific new paper from one of my classmates about #ImmuneCheckpointInhibitor induced #myocarditis. This work finds that CD8+ T-cells are the critical mediator of heart inflammation, and identifies the alpha-myosin cardiac protein as a candidate autoantigen: https://www.nature.com/articles/s41586-022-05432-3 #science #medicine #immunology #cardiology #oncology #Tcell #genomics #scRNAseq

Our pre-print "A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection" highlighted by the #FredHutch Science Spotlight team https://www.fredhutch.org/en/news/spotlight/2022/11/HB-Kulsuptrakul-BioRxiv.html

Work lead by MCBSeattle graduate student @Jkulsuptrakul co-mentored with @psmitchej

Excellent new paper from Kyle David finding evidence for a latitudinal gradient of polyploidy in animals. This is similar to what has been observed in plants for many years! Really wonderful! Also good to see our recently published Animal Chromosome Count Database used for the analyses!

#Polyploidy #Animals #Chromosomes #LatitudinalGradient

https://www.pnas.org/doi/10.1073/pnas.2214070119

https://onlinelibrary.wiley.com/doi/abs/10.1111/jeb.13884

Neutrophils are immune cells that do a lot of traveling (through the blood and into tissues) to get to sites of infection. Their large and stiff nuclei might it difficult for them to navigate through small spaces in tissues. So, how do they do it? Calì, Vargas, Viola, and colleagues showed that the signal that recruits neutrophils to target sites also makes their nuclei pliable so that they can squeeze through the gaps! Check out the study here: https://www.science.org/doi/10.1126/scisignal.abk2552 #science #immunology

Exciting 4 yr BBSRC DTP PhD opportunity: investigating the links between cytoskeletal & mitochondrial homeostasis during ageing. A multidiscipl. collab. of 2 experienced groups: Sanchez-Soriano (Liverpool) & Korolchuk (Newcastle). DEADLINE: Mon, 9 Jan '23

https://www.findaphd.com/phds/project/investigating-the-connection-between-cytoskeletal-and-mitochondrial-homeostasis-during-ageing/?p150425

In the upper right corner of the room we see the usual artifacts of the so-called book industry: a bound book, an unbound book, loose paper sheets in different formats, fresh and used papers. A learned setting and everyday business of dealing with paper and knowledge. This is what #BookHistory usually looks at. All these old and new, big and small books, and all kind of bookish formats were paper products, paper worlds made of paper. #BookHistory of early modern Europe is #PaperHistory.

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