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"In this review, we discuss the current developments in elucidating the role of the Drosophila Toll signaling pathway in immunity. We discuss the emerging role of Toll in viral infections and sex-specific differences in immunity. Mainly, we focus on Toll pathway regulation, the effector molecules, and cellular immunity"

journals.aai.org/jimmunol/arti

Continuing the holiday celebration on Day 2 (of 10). Topic: Modern and fascinating ideas about the brain for us all to discuss. How likely is each idea to be true? And if true, what are the implications?

Brain idea 9: Across different individuals, the same brain functions are implemented by biological details that vary a lot. This is true even for simple circuits like the ones that control the stomach of a crab, where the numbers of ion channels can vary 2-6x across different crabs but the circuit always does the same thing.

The friendly version:
quantamagazine.org/eve-marder-

The deeper dive:
sciencedirect.com/science/arti

#neuroscience
(And because I'm trying to work out the hashtag habit here ...)
#BrainIdeasCountdown

Physicist Freeman Dyson was born #OTD in 1923.

He was known for his work in quantum electrodynamics and – among many other things – his eschatological musings about physics and the prospects for life in the far-flung future.

To the best of my knowledge, Dyson was the most prominent physicist of the modern era who never completed a PhD.

Photo: Heka Davis / AIP

Agree with paper presenting #EBI resources: #biocuration and #metadata are critical for "training sets for deep learning, machine learning and artificial intelligence applications" in the life sciences #bioinformatics #machinelearning
academic.oup.com/nar/advance-a

A mob of red deer stags in Richmond Park, they were on the edge of the woods and unless you stopped to look from most angles they were perfectly hidden, I crouched down to take the shot, that's when I could see how many there were (shot with a long lens it looks like I was a lot closer than I actually was). #RichmondPark #RedDeer #Stags #RedStags #WildLifePhotography #Nature #Photography #AltText

A small study in France showed a 10% vaccine failure rate in people who got a single dose of #mpox vaccine after an exposure event. People who developed the infection had mild symptoms. In Eurosurveillance. eurosurveillance.org/content/1

@kristinmbranson My favorite subgenre are the M&Ms that cite a paper in the "as previously described in ref X" and then when you check, X is a review article.

RT @yule_wu@twitter.com

I am thrilled that my PhD work is now published in Nature Methods. In @JonasRies@twitter.com Ries group at @EMBLHeidelberg@twitter.com , I developed a new tool to extract meaningful parameters from macromolecular structures in SMLM data. nature.com/articles/s41592-022

🐦🔗: twitter.com/yule_wu/status/160

"Scientists learn to be authors by reading what has gone before and acquainting themselves with the literature. It’s clear then, that researchers pick up the unspoken message that method sections should be short, and minimal on detail."

news.cancerresearchuk.org/2022

Did you miss the info session on ERC grant applications for researchers based in the 🇨🇿Czech Republic ?

Catch up 👇 on useful tips from National Contact Points and host institutions.

Programme 👉 erc.europa.eu/news-events/even

@UniKarlova @Akademie_ved_CR youtu.be/QzcnEuTu91k

🐦🔗: n.respublicae.eu/ERC_Research/

Extensive Recombination-driven Coronavirus Diversification Expands the Pool of Potential Pandemic Pathogens buff.ly/3hnwIwT #science #evolution #biology #genomes #SciComm

It’s cold and snowy here in Cambridge so we’re thinking ahead to our “Imaging Cell Dynamics” journal meeting in Lisbon next year! The early-bird registration deadline is tomorrow (Friday) so apply now to avoid missing out (and please spread the word to anyone who might be Interested).
biologists.com/meetings/celldy #cellbio #cellbiology #imaging #microscopy

“Writing, at its best, is a lonely life.”

Hemingway's short, spectacular Nobel Prize acceptance speech themarginalian.org/2013/03/21/

@sergiod Reminds me of one of my favorite passages in Kurt Vonnegut's Mother Night

“There are plenty of good reasons for fighting,' I said, 'but no good reason ever to hate without reservation, to imagine that God Almighty Himself hates with you, too. Where's evil? It's that large part of every man that wants to hate without limit, that wants to hate with God on its side."

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