Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
I am pretty solidly on board with the public-private partnership behind many pharma success stories.
But Moderna’s ridiculous proposed markup of a Covid vaccine, when development was subsidized by taxpayers, is reprehensible.
They are proposing a price as high as $130 per dose, when it costs less than $3 to make.
Thiago Carvalho
boosted
RT @simocristea@twitter.com
‼️Why do we say that #methodsmatter?
Here’s a telling example.
Two very recent studies asked the exact same cancer #immunotherapy prediction question, on the exact same dataset.
They reached contradictory conclusions.
Why?
Slight changes in the #Bioinformatics methods used👇 https://twitter.com/ncieytanruppin/status/1610202233521438721
🐦🔗: https://twitter.com/simocristea/status/1613542247093653512
'The young of large-brained species, if left to grow their own brain, would face a seemingly insurmountable energetic constraint, because brain tissue is energetically costly but adequate cognitive benefits arise only after a delay. We therefore hypothesize that protracted parental provisioning was a precondition for the evolution of large brains.'
"Møllgård et al. found a fourth meningeal layer called the subarachnoid lymphatic-like membrane (SLYM). SLYM is immunophenotypically distinct from the other meningeal layers in the human and mouse brain and represents a tight barrier for solutes of more than 3 kilodaltons, effectively subdividing the subarachnoid space into two different compartments."
Thiago Carvalho
boosted
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
Thiago Carvalho
boosted
RT @stephaniehicks@twitter.com
I taught two 8-wk courses this fall @JohnsHopkinsSPH@twitter.com and wanted to share the resources (built in #quarto!) in case others starting in #Rstats #DataScience find it useful
🤩 Intro to R
https://www.stephaniehicks.com/jhustatcomputing2022/schedule
💃 More adv R #Git #CommandLine #SQL #APIs
https://www.stephaniehicks.com/jhustatprogramming2022/schedule
🐦🔗: https://twitter.com/stephaniehicks/status/1613500868271161346
Thiago Carvalho
boosted
A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of #DNA coiled around a core of histones. Explore the x-ray crystallography data and #3Dprint the #Nucleosome COMPASS Complex. #genetics #biotech #CRISP https://buff.ly/3Xo6Dx3
ON meeting your heroes
(From Gabriel Byrne's "Walking with Ghosts: A Memoir")
Thiago Carvalho
boosted
A critical period of prehearing spontaneous #calcium #spiking is required for #hairbundle maintenance in inner hair cells
Walter Marcotti and colleagues Sheffield University
https://www.embopress.org/doi/full/10.15252/embj.2022112118
Thiago Carvalho
boosted
🎉 Included in our Top 100 Downloaded Articles in 2022 Collection. Explore 'Whole Inactivated Virus and Protein-Based COVID-19 Vaccines' by Maria Elena Bottazzi and Peter J. Hotez, either #OpenAccess or freely available to download through the collection https://arevie.ws/3X9pD2A
'On June 28, 2022, researchers from Pfizer–BioNTech and Moderna presented data on their bivalent vaccines to the FDA’s Vaccines and Related Biological Products Advisory Committee (of which I am a member). The results were underwhelming. Bivalent boosters resulted in levels of neutralizing antibodies against BA.1 that were only 1.5 to 1.75 times as high as those achieved with monovalent boosters.'
Thiago Carvalho
boosted
Great collaborative effort with the Laurent Terradot team on two new #Brucella effectors modulating nuclear proteins just published in Nature Communications. Massive work by outstanding young scientists Arthur Louche and Amandine Blanco who combined #StructuralBiology, #InfectionBiology and a bit of mythology for naming the proteins, and ended up with a lot more questions than when we started!
Congrats to all involved
#Microbiology #Bacterial #Pathogenesis
https://www.nature.com/articles/s41467-022-35763-8
Thiago Carvalho
boosted
A review paper from @lapassmore on transcription termination @MolecularCell
"Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII"
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01178-9
Thiago Carvalho
boosted
New open access review out by Paddy Gibson and myself in Current Opinion in Microbiology on bacterial/#pneumococcal cell wall biology and penicillin/amoxicillin resistance. Issue edited by @goleylab Peter Chien. Lot's of new insights into bacterial cell wall biology have been made recently and we tried to cover it all. I really like this figure as it nicely highlights our current knowledge gaps and big open questions in the field.
https://www.sciencedirect.com/science/article/pii/S136952742200145X
Thiago Carvalho
boosted
RT @GuertinLab@twitter.com
The Cold Spring Harbor Gene Expression course is such an immersive experience, learning molecular biology and genomics methods, 2 hour interactive seminars with new and old scientists leading the field—apply: https://meetings.cshl.edu/courses.aspx?course=C-gnx&year=23
🐦🔗: https://twitter.com/GuertinLab/status/1613255371665055746
'Long-lasting sepsis-induced immunoparalysis has been principally studied in primary (1°) memory CD8 T cells; however, the impact of sepsis on memory CD8 T cells with a history of repeated cognate Ag encounters is largely unknown but important in understanding the role of sepsis in shaping the pre-existing memory CD8 T cell compartment.'
'A surge in winter sickness in the northern hemisphere and reduced exports from China have meant patients have found it difficult to get hold of some basic medicines such as penicillin and paracetamol. Almost all 27 EU member states and the UK have reported shortages.
Under pressure from governments, the commission has said it will intervene to ensure “strategic autonomy” in basic medicines through a “systemic industrial policy”.
https://www.ft.com/content/40de511f-7203-4d60-b33d-695d2360e349
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
