Thiago Carvalho @cyrilpedia@social.cleverlibre.org

The Nobelist as Hamlet - an illustration by Madalena (https://madalenaparreira.com) for a review I wrote of Prusiner's 2014 autobiography, "Madness and Memory: The Discovery of Prions".

https://madalenaparreira.com

@NicoleCRust There's a famous letter Raymond Chandler wrote to an editor at The Atlantic, which includes this brilliant quote:

"Would you convey my compliments to the purist who reads your proofs and tell him or her that I write in a sort of broken-down patois which is something like the way a Swiss waiter talks, and that when I split an infinitive, God damn it, I split it so it will stay split, and when I interrupt the velvety smoothness of my more or less literate syntax with a few sudden words of barroom vernacular, this is done with the eyes wide open and the mind relaxed but attentive. The method may not be perfect, but it is all I have."

@NicoleCRust Fair enough - but Owen did open the article stating that this is a pet peeve, we're all entitled to some....

"Where Brod strove to clean Kafka up and foster a sense that he was, in Benjamin’s words, a “saintly, prophetic genius, whose purity places him at an elevated remove from the world,” this edition scuffs him up and returns him to earth, in an intimate manner that does no injury to our sense of his suffering, or his profound and original gifts."

https://www.nytimes.com/2023/01/11/books/kafka-diaries.html

"The differential effects of anti-CD20 treatment on CD4+ and CD8+ T cell subsets point to different contributions of direct removal of CD20-expressing T cells, as well as indirect effects likely reflecting the removal of B cells that alters in vivo T cell:B cell interactions."

#Immunology #MultipleSclerosis #Immunotherapy #Autoimmunity #CD20

https://www.pnas.org/doi/10.1073/pnas.2207291120

'Every sensitive reader has pet peeves. One of mine is attributing the power of sight to things that don’t have eyes, as in this sentence from the Wall Street Journal: “Restaurant sales are expected to see a warming trend this spring as menu prices rise and consumers spend more.”

https://www.newyorker.com/culture/annals-of-inquiry/the-objectively-objectionable-grammatical-pet-peeve

A shot from a spectacular film, Francesco Rosi's "Cristo si è fermato a Eboli" (Christ Stopped at Eboli).

'Mitonuclear interactions would therefore exert an influence on evolutionary trajectories. One prediction from this model is that the same nuclear genomes but evolving with different mitochondrial haplotypes would follow distinct molecular paths towards higher fitness peaks.'

#Evolution #EvolutionaryBiology #preprint #mitochondria

https://www.biorxiv.org/content/10.1101/2022.09.11.507487v3

Nautilus

“Anderson Torres took over as secretary of security, dismissed the entire command and travelled,” says Ricardo Cappelli, the federal government official who is temporarily in charge of security in Brasília. “If this isn’t sabotage, I don’t know what is.”

https://www.ft.com/content/a6143da4-50ae-4a69-ba29-190a8bfa37c1

"Here, we show that cGAMP delivery by intratumoral injection of virus-like particles (cGAMP-VLP) led to differentiation of circulating tumor-specific T cells, decreased tumor regulatory T cells (Tregs), and antitumoral responses that synergized with PD1 blockade."

#STING #Immunology #Immunotherapy #checkpointinhibitors

https://www.science.org/doi/10.1126/sciimmunol.abn6612#.Y8G4gZis1IU.twitter

'When ‘precolonial’ is used for describing African ideas, processes, institutions and practices, through time, it misrepresents them. When deployed to explain African experience and institutions, and characterise the logic of their evolution through history, it is worthless and theoretically vacuous. The concept of ‘precolonial’ anything hides, it never discloses; it obscures, it never illuminates; it does not aid understanding in any manner, shape or form.'

Olúfẹ́mi Táíwò @aeon_co

https://aeon.co/essays/the-idea-of-precolonial-africa-is-vacuous-and-wrong

'La petición se basa en que el político ultraderechista publicó este martes, dos días después de la invasión protagonizada por miles de sus seguidores, un vídeo en redes sociales que eliminó después. En el clip, un fiscal bolsonarista ponía en duda el resultado de las últimas elecciones, que Bolsonaro perdió frente a Luiz Inácio Lula da Silva, presidente desde hace 13 días.'

https://elpais.com/internacional/2023-01-13/la-fiscalia-de-brasil-pide-que-el-expresidente-bolsonaro-sea-investigado-por-el-asalto-en-brasilia.html