Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
RT @MiltonBituca
"Aí a dor vai nos unir, o fim da dor começa, é assim..."
Yanomami e Nós - Pacto da Vida
(Milton Nascimento e Fernando Brant)
Thiago Carvalho
boosted
This #EMmonday we’re looking at microvesicle release from inner segments of #photoreceptors. #TEM image shows microvesicle next to endocytic, clathrin-coated pit.
📖 @DMM_Journal: https://doi.org/10.1242/dmm.049871
#Microvesicle #Retina #Vision #Science #FocalPlane #Biology #Imaging
"In this issue of Nature Medicine, Yap et al.4 report on a phase I trial evaluating a potent mitochondrial inhibitor5 (IACS-010759) in individuals with acute myeloid leukemia and solid tumors. Unfortunately, promising preclinical findings did not translate into the clinic as intolerable neurotoxicity precluded adequate dosing, prompting the question — what lessons can be learned from this disappointing outcome?"
Thiago Carvalho
boosted
Here's a cute submission for #MicroscopyMonday ❤️ Shown is a primary cilium from an IMCD3 cell labeled with acetylated alpha-tubulin in red. Smoothened, the GPCR that is activated downstream of Sonic Hedgehog signals, is shown in green. To make the heart, the cilium image was duplicated and flipped using Photoshop. Have a great week!
Thiago Carvalho
boosted
Interesting @biorxivpreprint by the group of Keriann Backus. They combine compartment-localized TurboID with cysteine-directed chemoproteomics to enrich cysteines of several cellular compartments using a two step enrichment strategy. This e.g. allows studying the oxidation state of many cysteines in the specific compartment. https://doi.org/10.1101/2023.01.22.525042
Thiago Carvalho
boosted
RT @IGDRennes
We are launching the 2nd @IGDRennes PhD program call. Apply before April 28th https://igdr.univ-rennes.fr/en/application-igdr-phd-program
5-7 positions will be available to work in one the 15 research teams @CNRS @CNRS_dr17 @RennesUniv @InsermGrdOuest @SBCF1 @sfbd_biodev
Thiago Carvalho
boosted
"How models with advanced natural language processing capabilities can be used to reduce the time-consuming process of writing and revising scholarly manuscripts
These models can capture the concepts in the scholarly text and produce high-quality revisions that improve clarity"
via @greenescientist https://www.biorxiv.org/content/10.1101/2023.01.21.525030v1
Thiago Carvalho
boosted
A shrine among trees on a moor #hiroshige #utagawahiroshige https://www.wikiart.org/en/hiroshige/a-shrine-among-trees-on-a-moor
'But if healthy people who like to take risks are not in the pool, insurance becomes prohibitively expensive and insurance companies expend huge effort on excluding those most likely to need it. That way lies the US disaster — the world’s most expensive and least effective health system.'
https://www.ft.com/content/602fa4cc-8de9-456c-88b7-480265c911a0
'Still, the threat of political violence remains real; in December, police stopped a bomb plot against Lula. People close to him are particularly concerned about the military, and perplexed by its reluctance to quell the violence on January 8th.'
https://www.newyorker.com/magazine/2023/01/30/after-bolsonaro-can-lula-remake-brazil
'We show how uncertainty in measurements of natural selection, or low predictability of external environmental factors affecting selection, can greatly reduce predictive power, often swamping the influence of intrinsic randomness caused by genetic drift.'
@NicoleCRust
Conserved toll signalling in C elegans beyond redeployed from traditional innate immunity in arthropods & vertebrates to expression in the brain mediation behavioural pathogen avoidance in nematodes
Thiago Carvalho
boosted
What are your favorite examples of genes that are preserved across different species (say worms/flies to mice to humans) that do interesting brain-related things?
The gene whose mutation leads to Huntington's disease (Huntingtin) is one example. Others?
Thiago Carvalho
boosted
Our latest! A 🧵 . Led by Nathan Harris & Sam Bates we ask: How does #experience modify neuronal #gene expression to drive #plasticity?
We find that multiple #stimulus features can be encoded in the gene expression program of a single #sensory neuron and we show how this underlies specific neuronal & behavioral plasticity.
Of course, this Q has been addressed by many others in landmark papers by the Greenberg lab, @Datta_Lab, Jesse Gray & many others. 1/n
Thiago Carvalho
boosted
"Medicine at the Crick | Escaping the antibiotic apocalypse"
Looks an interesting meeting with a good title! #AMR #IDMastodon #MedMastodon
https://www.crick.ac.uk/whats-on/medicine-at-the-crick-escaping-the-antibiotic-apocalypse
Thiago Carvalho
boosted
For those in #neuroscience or adjacent, I've made an instance at
https://synapse.cafe/
Come join us! We still have capacity for quite a bit more people.
"During 2020, they enrolled and compared people who had recovered from mild COVID-19 with age- and sex-matched control participants who had never had the disease. They were surprised to find that male recoverees had better responses to vaccination against influenza than those of female recoverees (and also had better responses than those of males who never had COVID-19)."
'About 80% of China’s population has been infected with Covid-19 since restrictions were lifted in early December, Chinese health authorities have said.
The figure, which equates to about 1.2 billion people, prompted some pandemic experts to estimate that more than 1 million may have died – far more than the government’s official tally of about 72,000.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
