Thiago Carvalho @cyrilpedia@social.cleverlibre.org

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🦠 A Few Mpox ( #monkeypox ) Pandemic Updates 🦠

When did the current #mpox (MPXV) pandemic start?

Although it first caught attention in 2022, some have traced the current pandemic back to 2017.

A new research letter, however, reports that "our analyses of MPXV genome sequences indicate that the virus has been circulating silently and undetected for about 2 decades."
https://wwwnc.cdc.gov/eid/article/29/2/22-0962_article
h/t @travelhealthdoc

#virus #virology @virology #epidemiology #InfectiousDisease

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So, where are we now?

US CDC case reports have slowed down to "only" 47 this year so far, with a total of 30,000 reports and 23 deaths in the US:
https://www.cdc.gov/poxvirus/monkeypox/response/2022/mpx-trends.html

But the latest WHO biweekly report noted that "11 countries reported an increase in the weekly number of cases,
with the highest increase reported in Mexico," along with 5 new deaths in South America:
https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox--external-situation-report-14--19-january-2023

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How RNA viruses can use their dsRNA intermediate state as a de facto latent state, facilitating viral persistence.

Positive single-stranded RNA viruses have a replication cycle that includes a double-stranded RNA (dsRNA) intermediate state.

January 24, 1839, Charles #Darwin elected Fellow of the Royal Society for his geological 🪨 and biological 🐢 research done during the voyage of the Beagle ⛵

https://tinyurl.com/yxm9rn3g

January 24, 1911, the French Academy of Sciences rejects Marie Curie's nomination, despite public support of some members. 10 months later she is awarded the Nobel prize "for the discovery of radium and polonium"
🏅
Pic shows polonium-halo in biotite ☢️🪨

Very happy to see this article coming out of our lab! "Precision targeting of autoantigen-specific B cells in MuSK myasthenia gravis with chimeric autoantibody receptor T cells" #immunology #AutoImmunity #biotechnology https://www.nature.com/articles/s41587-022-01637-z

Cool! #Evolution in action!

"Native eastern fence lizards changed their bodies and behavior in response to invasive red imported fire ants"

https://theconversation.com/native-eastern-fence-lizards-changed-their-bodies-and-behavior-in-response-to-invasive-red-imported-fire-ants-186275

Our latest #preprint describes how #Pot1 promotes DNA #replication by recruiting #Stn1 to #telomeres. Great collaboration with S Coulon, CRCM Marseille. My last fission yeast paper! 😢 Thanks my yeast colleagues and friends! ♥️

https://www.biorxiv.org/content/10.1101/2023.01.23.525167v1

#GeneRegulation couples transfers of information to transfers of mass and energy. The E. coli Trp-operon is often used as a simple example of gene reg. Genetic info transfers from #DNA to #proteins, including the synthesis of (1) a #repressor gene. In absence of tryptophan, the #operon induces the synthesis of the #metabolic #enzymes for its production (2). Tryptophan then binds the repressor (3)...

Wolbachia are #endosymbionts that manipulate their hosts' reproductive biology. @EmmelienV @blaxterlab describe genomes of 110 #Wolbachia coincidentally sequenced alongside their insect hosts, finding a rich diversity of host manipulation loci #PLOSBiology https://plos.io/3DarU62

For more information, hear the EMBO podcast on the discovery of ALT: https://www.embo.org/podcasts/alternative-immortality/

JOB:

at the Computational Social Science Dept. at GESIS we are looking for a Research Software Engineer. The person will work on cutting-edge infrastructure for digital behavioral data.

Permanent position & detailed onboarding. Anyone with related #datascience skills can apply, independent of disciplinary background.

TVL-13, permanent postion.

Office located in Cologne, up to 60% remote work possible.

Feel free to message me with questions

https://www.hidden-professionals.de/HPv3.Jobs/gesis/stellenangebot/27897/Research-Software-Engineer-for-Digital-Behavioral-Data?lang=en-US