Thiago Carvalho @cyrilpedia@social.cleverlibre.org

In Aicardi-Goutières syndrome patient samples

"Using machine-learning approaches and differential gene expression we identified a drastic loss of transcription factor hypoxia induced factor 1 alpha (HIF-1a) expression and activity associated with features of a metabolic switch and mitochondrial stress in monocytes/dendritic cells."

#Preprint #Immunology #geneticdisease

https://www.biorxiv.org/content/10.1101/2023.02.23.529707v1

Fits well with earlier work from Jocelyne's lab:

"Type I IFN sets the stringency of B cell repertoire selection in the bone marrow" (1999)

https://academic.oup.com/intimm/article/11/2/279/759572

and

"Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice" (2003)

https://www.sciencedirect.com/science/article/abs/pii/S0896841102001099

'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'

#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity

https://onlinelibrary.wiley.com/doi/10.1002/art.42482

"One of my current projects, called CryoEM-101 (http://cryoem101.org), is an online, media-rich course that provides practical guidance to those looking to learn about electron cryo-microscopy and tomography."

https://www.cell.com/current-biology/fulltext/S0960-9822(22)01958-3

"Here, we show that p53, one of the most commonly inactivated tumor suppressors in glioma, is a gatekeeper of astrocyte fate. In the context of stab-wound injury, p53 loss destabilized the identity of astrocytes, priming them to dedifferentiate in later life."

https://www.cell.com/current-biology/fulltext/S0960-9822(23)00152-5

'Diverse animals such as corals, polychaete worms, and certain fishes are thought to synchronize their reproductive behavior by the moon. Such animals—including more than 100 coral species at the Great Barrier Reef—release their eggs before fertilization takes place, and synchronization maximizes the probability of an encounter between eggs and sperm.'

https://www.theatlantic.com/science/archive/2023/02/moon-control-biological-rhythms-lunar-cycle/673213/

Great cover for the current issue of @CellMetabolism

https://www.cell.com/issue/S1550-4131(22)X0003-X#

@sentient_water The previous vice chancellor, Louise Richardson, actively defended the policy:

"She has warned against the “cancellation” of benefactors, whether the colonialist Cecil Rhodes or the opioid-seller Mortimer Sackler. "

https://www.ft.com/content/b6e002a6-4fab-49c5-977b-a6f49d38d52e

"The US price of Humira, which AbbVie has increased more than 20 times to exploit its monopoly there, is finally under pressure. Having been legally shielded until now, the drug this year faces competition from nine “biosimilars” such as Amgen’s Amjevita. This may bring relief to patients who have faced bills of thousands of dollars, despite being insured."

https://www.ft.com/content/a8685c8d-60da-4fe8-9bba-ec1ba3bf62cc

"When I was a young person, libraries were where I went to find stories that made me feel I could fit in, not only in North Dakota, but in the wider world. But two pieces of legislation that may soon be signed into law in North Dakota would make it possible to restrict libraries and, in some cases, to imprison librarians."

https://www.nytimes.com/2023/02/24/opinion/libraries-sex-books-north-dakota.html

A step back for antivirals: the EMA gives molnupiravir thumbs down, based on the lack of strong evidence for efficacy.
#covid19 #covid

'La Agencia Europea del Medicamento (EMA) considera que la falta de eficacia del molnupiravir, comercializado como Lagevrio y que fue el primer tratamiento oral contra la covid utilizado de forma experimental durante la pandemia, hace que su comercialización y uso en los sistemas sanitarios no sea recomendable.'

https://elpais.com/sociedad/2023-02-24/la-ema-rechaza-la-comercializacion-del-primer-tratamiento-oral-contra-la-covid-por-falta-de-eficacia.html

'Toda una generación de niños de Caldes D‘Estrac, a 40 kilómetros de Barcelona, quedó marcada entre 1970 y 1975 por los abusos del sacerdote Josep Vendrell Cortasa, según denuncian al menos seis antiguos alumnos suyos en el colegio e internado del pueblo, donde era director, además de párroco de la iglesia de Santa María y responsable del grupo scout.'

https://elpais.com/sociedad/2023-02-25/un-cura-depredador-sexual-de-menores-paso-por-parroquias-de-barcelona-impune-y-encubierto-durante-tres-decadas.html

Progress.

"In my professional lifetime, neonatal mortality has gone from 30 per thousand to 5 per thousand. The babies I couldn’t take care of when I was a house staff now largely go home and live full lives. You wouldn’t believe how robust a baby is and how well they can heal and recover from real challenges."

https://www.jci.org/articles/view/168557

Bear.

#Ceramics #ArtMastodon #handmade

https://madalenaparreira.com/Hunchbacksociety

Had a great time yesterday opening the Algarve University Hospital Center's (CHUA) conference, speaking on the research origins of some of today's key drugs & the limits of translation.

And Rous' hen, of course :)

"Students and academics at Oxford university have called for a sweeping review of policies around its relationship with donors, following revelations that the elite institution courted the Sackler family even after others cut ties."

https://www.ft.com/content/6a42e764-46a1-4bdf-a76e-d548d78db8fc